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High flow nasal oxygen during sedation in the cardiac catheterisation laboratory

A randomized controlled trial

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  • Authors
  • Aaron Conway

    Peter Munk Cardiac Centre, UHN & Lawrence S. Bloomberg Faculty of Nursing, University of Toronto

  • Navpreet Kamboj

    Lawrence S. Bloomberg Faculty of Nursing, University of Toronto

  • Kristina Chang

    Toronto General Hospital, UHN

  • Matteo Parotto

    Toronto General Hospital, UHN

Methods

Overview

Overview

Screening

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CONSORT diagram

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Reasons for exclusion

Characteristics

Participant characteristics

Characteristic High Flow nasal oxygen, N = 641 Face mask oxygen, N = 651
Age (years) 67 (14) 70 (13)
Gender
Female 19 (30%) 17 (26%)
Male 45 (70%) 47 (72%)
Prefer not to say 0 (0%) 1 (1.5%)
Other 0 (0%) 0 (0%)
Smoking history
Never 23 (36%) 25 (38%)
Current 7 (11%) 7 (11%)
Past 34 (53%) 33 (51%)
Obstructive sleep apnea 17 (27%) 18 (28%)
Uses CPAP 9 (14%) 12 (18%)
Admission source
Ward 17 (27%) 18 (28%)
Day surgery 45 (70%) 44 (68%)
CVICU 2 (3.1%) 3 (4.6%)
CICU 0 (0%) 0 (0%)
ASA classification status
I 0 (0%) 0 (0%)
II 0 (0%) 0 (0%)
III 21 (33%) 16 (25%)
IV 43 (67%) 49 (75%)
Procedure
PPM 11 (17%) 17 (26%)
PPM generator change 6 (9.4%) 7 (11%)
PPM lead revision 0 (0%) 1 (1.5%)
ICD 19 (30%) 13 (20%)
ICD generator change 10 (16%) 13 (20%)
ICD lead revision 2 (3.1%) 0 (0%)
CRT-D 11 (17%) 11 (17%)
CRT-P 2 (3.1%) 2 (3.1%)
Wound revision 0 (0%) 0 (0%)
Other 3 (4.7%) 1 (1.5%)
Charlson Comorbidity Index 4.46 (2.14) 5.15 (2.51)
Total dose of midazolam (mg) 1.58 (0.84) 1.45 (0.71)
Total dose of propofol (mg) 100 (126) 88 (104)
Total dose of fentanyl (mcg) 71 (28) 76 (56)

1 Statistics presented: mean (SD); n (%)

Oxygen use

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Oxygen flow rate in litres per minute for each participant

Oxygen flow rate in litres per minute as a proportion of the total time of all procedures per randomization group

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Oxygen to air ratio for each participant randomized to high flow nasal oxygen

Main results

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CO2/SPO2 data

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Categories of recorded CO2 values during procedure for each participant

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Categories of recorded SPO2 values during procedure for each participant

Codebook

Insert a codebook: https://rubenarslan.github.io/codebook/

View and download data

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Data